The main findings reported above were consistent when analyzing only subjects with smoking history 50 ppb]).Īll athletes demonstrated normal baseline lung function (FEV1 % predicted > 80%). 24% for B-Eos, respectively (all P-values .05). FAO was defined as postbronchodilator FEV1/FVC-ratio under lower limit of normal.īoth subjects with asthma without FAO (n = 755) and subjects with asthma with FAO (n = 220) were characterized by larger prevalence of elevated FeNO (>=25 ppb) and elevated B-Eos (>=300 cells/mm3) than non-asthmatic subjects without FAO (controls) (n = 11434): 30% and 34% vs 18% for FeNO and 31%, 47% vs. We included 13387 participants, aged 20-80 years, from the National Health and Nutrition Examination Survey years 2007-08, 2009-12 with available FeNO, B-Eos and spirometry data. A secondary aim was to study if type 2 inflammation is found in non-asthmatic subjects with FAO. The main aim of this study was to investigate if type 2 inflammation, assessed by exhaled nitric oxide (FeNO) and blood eosinophils (B-Eos), is found to a larger extent in asthma subjects with FAO.
Mogensen I 1, Alving K 1, Jacinto T 2, Fonseca J 2, Janson C 1, Malinovschi A 1ġUppsala University, Uppsala, Sweden 2Porto University, Porto, Portugalįixed airflow obstruction (FAO) occurs in a subtype of asthma that is associated to more symptoms, poorer response to treatment and worse prognosis. MECHANISMS AND BIOMARKERS IN ASTHMA OA0001 | Fixed airflow obstruction in presence of asthma is associated with elevated blood eosinophils
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